APRESIGN 30 TAB - Dr Precision

APRESIGN 30 Tablet is a well-tolerated oral medication containing Apremilast 30 mg, primarily used in the treatment of psoriatic arthritis and moderate to severe plaque psoriasis in adults who are candidates for systemic therapy or phototherapy. Apremilast is a PDE4 inhibitor that works by modulating the immune response, thereby reducing inflammation and controlling disease symptoms.

The therapy offers an oral, non-immunosuppressive alternative to biologic agents, making it a convenient choice for long-term treatment with a favorable safety profile.

Apremilast inhibits the enzyme phosphodiesterase 4 (PDE4), leading to increased intracellular cAMP levels. This modulation results in a downregulation of pro-inflammatory mediators such as TNF-α, IL-17, and IL-23, and an increase in anti-inflammatory mediators, helping to control psoriatic and arthritic symptoms effectively.

Dosage and Administration:

Titration required to reduce risk of GI side effects during initiation:

Day 1: 10 mg in morning

Day 2: 10 mg morning, 10 mg evening

Day 3: 10 mg morning, 20 mg evening

Day 4: 20 mg morning, 20 mg evening

Day 5: 20 mg morning, 30 mg evening

Day 6 onward: 30 mg twice daily

Swallow whole with or without food

No dosage adjustment typically required for mild renal/hepatic impairment