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1-Hydroxy benzotriazole monohydrate (HOBT)

Avd Pharmaceuticals Private Limited logo
Avd Pharmaceuticals Private Limited
Service Provider , Manufacturer, Distributor, Exporter, Startup — Pimpri-Chinchwad, Maharashtra, India · Replies in ~24–48 hours
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₹ 19.04 /unit ₹ 23.81 You save ₹ 4.77 In stock
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MOQ: 1 unit
Lead time: On request
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Origin: India
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Minimum order
1 unit
HSN Code
On request
Origin
India
Lead time
On request
Port of dispatch
On request
Packaging
Standard export packaging
Shelf life / storage
As per product specification
Export markets served
Global markets
Ability to customise
As per OEM brief
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Company Avd Pharmaceuticals Private Limited
Avd Pharmaceuticals Private Limited logo
Avd Pharmaceuticals Private Limited

Manufacturer of Research Chemicals, Drug Substances, Drug Intermediates, Impurities, Specialty Chemicals, and Provider of Job Work & Toll Manufacturing Services for Pharmaceutical and Chemical Companies

Registered address: Pune, India. Industry: Chemicals, Dyes & Paints › Chemicals, Compounds & Formulations.

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Established
2022
Employees
11–30
GST
27AAXCA5614Q1ZS
IEC code
Not shared
Export markets
Global markets
Member since
Jun 2025
Turnover
$250,000 - $1 MM
Incorporation type
On request
Product details

1-Hydroxybenzotriazole Monohydrate (HOBT Monohydrate)

Description:
1-Hydroxybenzotriazole monohydrate is a white crystalline solid commonly used as a coupling reagent in peptide synthesis and other organic transformations. It enhances the efficiency of amide bond formation by suppressing racemization and stabilizing active esters. This hydrated form is particularly favored for its better handling characteristics and ease of dissolution. It is used extensively in pharmaceutical R&D and industrial peptide manufacturing. Due to its potential for explosive decomposition under heat or friction, it must be handled with strict safety precautions.

Product Summary:

  • CAS Number: 123333-53-9

  • Molecular Formula: C6H5N3O·H2O

  • Molecular Weight: 155.14 g/mol

  • Synonyms: HOBt·H2O

  • Packaging: 25 kg fiber drum or HDPE container

  • Solubility: Soluble in DMF, DMSO, methanol

  • Storage: Store in cool, dry place, away from oxidizers

  • Toxicity: May cause irritation; handle with care

Applications:

  • Coupling reagent in peptide synthesis

  • Intermediate in drug synthesis

  • Research and development in organic chemistry

Description provided by Avd Pharmaceuticals Private Limited.

1-Hydroxybenzotriazole Monohydrate (HOBt·H2O)

White crystalline solid

Coupling reagent for peptide synthesis

Effectively reduces racemization during amide bond formation

Soluble in DMF, DMSO, methanol

Available in 25 kg fiber drums or HDPE containers

155.14 g/mol

Requires strict safety precautions due to explosive decomposition risk

Store in a cool, dry place away from oxidizers

Used in pharmaceutical R&D, industrial peptide manufacturing, and drug synthesis

Specifications
CAS Number
123333-53-9
Molecular Formula
C6H5N3O·H2O
Appearance
White crystalline solid
Solubility
Soluble in DMF, DMSO, methanol
Packaging Options
25 kg fiber drum or HDPE container
Storage
Cool, dry place, away from oxidizers
Molecular Weight
155.14 g/mol
Toxicity
May cause irritation; handle with care
Stability
Stable under recommended storage; avoid heat and friction
Use cases
Category
healthcare > apis > api intermediate
Primary application
Brand
Not specified
Product type
Product
Logistics & handling
Lead time
On request
Packaging
As per buyer requirement
Storage condition
As recommended by supplier
Origin
India
Form
As listed by supplier
Commercials Avd Pharmaceuticals Private Limited
Minimum order
1 unit
Lead time
On request
Payment terms
As per negotiated commercial agreement
Frequently asked by buyers
What advantages does the monohydrate form of HOBt offer compared to anhydrous HOBt?

The monohydrate form of HOBt offers improved handling characteristics and better solubility in common organic solvents such as DMF, DMSO, and methanol, facilitating easier dissolution during peptide coupling reactions. Additionally, it tends to be more stable and safer to handle than the anhydrous form under industrial manufacturing conditions.

How does 1-Hydroxybenzotriazole monohydrate suppress racemization during peptide synthesis?

1-Hydroxybenzotriazole monohydrate stabilizes intermediate active esters formed during the coupling step, which minimizes epimerization or racemization of chiral centers by reducing the lifetime of reactive intermediates susceptible to stereochemical inversion.

What safety precautions are necessary when handling HOBt monohydrate in bulk?

Due to its potential for explosive decomposition when exposed to heat or friction, strict safety protocols including storage in a cool, dry area away from oxidizing agents, use of protective equipment, controlled handling procedures, and proper ventilation must be observed.

For which industries is 1-Hydroxybenzotriazole monohydrate primarily used?

This compound is primarily used in pharmaceutical research and development, industrial peptide manufacturing, and as an intermediate in drug synthesis and other organic chemical processes.

What solvents is HOBt monohydrate most soluble in for organic synthesis applications?

HOBt monohydrate shows high solubility in solvents like N,N-Dimethylformamide (DMF), Dimethyl sulfoxide (DMSO), and methanol, which are commonly used in peptide coupling and related organic synthesis processes.

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1-Hydroxy benzotriazole monohydrate (HOBT)
1-Hydroxy benzotriazole monohydrate (HOBT)
₹ 19.04 /unit