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1-Hydroxy benzotriazole monohydrate (HOBT)

Name: 1-Hydroxy benzotriazole monohydrate (HOBT)
SKU: 8494061
Price: 19.04 USD
Availability: InStock

Sold by avd pharmaceuticals private limited · Service Provider , Manufacturer, Distributor, Exporter, Startup · Pimpri-Chinchwad, Maharashtra, India

Price

₹ 19.04 /unit

In stock

MRP ~~₹ 23.81~~

Inclusive of all taxes

You Save: ₹ 4.77

Minimum order: 1 unit

Export Snapshot

MOQ

1 unit

Lead time

On request

Packaging

Standard export packaging

Shelf life / longevity

As per product specification

HSN Code

On request

Origin

India

Port of dispatch

On request

Export markets served

Global markets

Values shown are for avd pharmaceuticals private limited.

Suitable for

Importers · Distributors · Wholesalers

Pimpri-Chinchwad Dispatch on request Verified seller

avd pharmaceuticals private limited

Service Provider , Manufacturer, Distributor, Exporter, Startup · Pimpri-Chinchwad, Maharashtra, India

Manufacturer of Research Chemicals, Drug Substances, Drug Intermediates, Impurities, Specialty Chemicals, and Provider of Job Work & Toll Manufacturing Services for Pharmaceutical and Chemical Companies

Registered address: Pune, India. Industry: Chemicals, Dyes & Paints > Chemicals, Compounds & Formulations.

View profile All products

Established

2022

Employees

11–30

GST

27AAXCA5614Q1ZS

IEC code

Not shared

Export markets

Global markets

GlobalLinker Member Since

Jun 2025

Turnover

$250,000 - $1 MM

Incorporation Type

On request

Certifications & Awards

Product details

What are the specifications of this product?

Overview

Description: 1-Hydroxybenzotriazole monohydrate is a white crystalline solid commonly used as a coupling reagent in peptide synthesis and other organic transformations. It enhances the efficiency of amide bond formation by suppressing racemization and stabilizing active esters. This hydrated form is particularly favored for its better handling characteristics and ease of dissolution. It is used extensively in pharmaceutical R&D and industrial peptide manufacturing. Due to its potential for explosive decomposition under heat or friction, it must be handled with strict safety precautions.

Product Description

1-Hydroxybenzotriazole Monohydrate (HOBT Monohydrate)

Description:
1-Hydroxybenzotriazole monohydrate is a white crystalline solid commonly used as a coupling reagent in peptide synthesis and other organic transformations. It enhances the efficiency of amide bond formation by suppressing racemization and stabilizing active esters. This hydrated form is particularly favored for its better handling characteristics and ease of dissolution. It is used extensively in pharmaceutical R&D and industrial peptide manufacturing. Due to its potential for explosive decomposition under heat or friction, it must be handled with strict safety precautions.

Product Summary:

CAS Number: 123333-53-9
Molecular Formula: C6H5N3O·H2O
Molecular Weight: 155.14 g/mol
Synonyms: HOBt·H2O
Packaging: 25 kg fiber drum or HDPE container
Solubility: Soluble in DMF, DMSO, methanol
Storage: Store in cool, dry place, away from oxidizers
Toxicity: May cause irritation; handle with care

Applications:

Coupling reagent in peptide synthesis
Intermediate in drug synthesis
Research and development in organic chemistry

Description provided by avd pharmaceuticals private limited.

Specifications

CAS Number	123333-53-9
Molecular Formula	C6H5N3O·H2O
Appearance	White crystalline solid
Solubility	Soluble in DMF, DMSO, methanol
Packaging Options	25 kg fiber drum or HDPE container
Storage	Cool, dry place, away from oxidizers
Molecular Weight	155.14 g/mol
Toxicity	May cause irritation; handle with care
Stability	Stable under recommended storage; avoid heat and friction

Use cases

Category	healthcare > apis > api intermediate
Primary application	Wholesale, distribution, and international sourcing
Brand	Not specified
Product type	Product

Logistics & handling

Lead time	On request
Packaging	As per buyer requirement
Storage condition	As recommended by supplier
Origin	India
Form	As listed by supplier

Commercials (this seller)

Minimum order	1 unit
Lead time	On request
Payment terms	As per negotiated commercial agreement.

Buyer questions

Frequently asked by buyers

Common questions B2B buyers ask before sourcing 1-Hydroxy benzotriazole monohydrate (HOBT). Answers compiled from verified sellers' commercial terms and platform data.

Q: What advantages does the monohydrate form of HOBt offer compared to anhydrous HOBt?

A: The monohydrate form of HOBt offers improved handling characteristics and better solubility in common organic solvents such as DMF, DMSO, and methanol, facilitating easier dissolution during peptide coupling reactions. Additionally, it tends to be more stable and safer to handle than the anhydrous form under industrial manufacturing conditions.

Q: How does 1-Hydroxybenzotriazole monohydrate suppress racemization during peptide synthesis?

A: 1-Hydroxybenzotriazole monohydrate stabilizes intermediate active esters formed during the coupling step, which minimizes epimerization or racemization of chiral centers by reducing the lifetime of reactive intermediates susceptible to stereochemical inversion.

Q: What safety precautions are necessary when handling HOBt monohydrate in bulk?

A: Due to its potential for explosive decomposition when exposed to heat or friction, strict safety protocols including storage in a cool, dry area away from oxidizing agents, use of protective equipment, controlled handling procedures, and proper ventilation must be observed.

Q: For which industries is 1-Hydroxybenzotriazole monohydrate primarily used?

A: This compound is primarily used in pharmaceutical research and development, industrial peptide manufacturing, and as an intermediate in drug synthesis and other organic chemical processes.

Q: What solvents is HOBt monohydrate most soluble in for organic synthesis applications?

A: HOBt monohydrate shows high solubility in solvents like N,N-Dimethylformamide (DMF), Dimethyl sulfoxide (DMSO), and methanol, which are commonly used in peptide coupling and related organic synthesis processes.

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