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1- Hydroxy benzotriazole anhydrous (HOBT)

Avd Pharmaceuticals Private Limited logo
Avd Pharmaceuticals Private Limited
Service Provider , Manufacturer, Distributor, Exporter, Startup — Pimpri-Chinchwad, Maharashtra, India · Replies in ~24–48 hours
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₹ 19.59 /unit ₹ 24.49 You save ₹ 4.90 In stock
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MOQ: 1 unit
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Origin: India
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1 unit
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On request
Origin
India
Lead time
On request
Port of dispatch
On request
Packaging
Standard export packaging
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As per product specification
Export markets served
Global markets
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Company Avd Pharmaceuticals Private Limited
Avd Pharmaceuticals Private Limited logo
Avd Pharmaceuticals Private Limited

Manufacturer of Research Chemicals, Drug Substances, Drug Intermediates, Impurities, Specialty Chemicals, and Provider of Job Work & Toll Manufacturing Services for Pharmaceutical and Chemical Companies

Registered address: Pune, India. Industry: Chemicals, Dyes & Paints › Chemicals, Compounds & Formulations.

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Established
2022
Employees
11–30
GST
27AAXCA5614Q1ZS
IEC code
Not shared
Export markets
Global markets
Member since
Jun 2025
Turnover
$250,000 - $1 MM
Incorporation type
On request
Product details

1-Hydroxybenzotriazole Anhydrous (HOBT Anhydrous)

Description:
1-Hydroxybenzotriazole anhydrous is a potent acylation catalyst and condensation agent used primarily in peptide bond formation. It prevents racemization and improves yields in carbodiimide-mediated coupling reactions. The anhydrous form is highly reactive and moisture-sensitive, often used in strictly anhydrous conditions for high-purity synthesis. It is valuable in the synthesis of pharmaceutical peptides, esters, and complex small molecules.

Product Summary:

  • CAS Number: 2592-95-2

  • Molecular Formula: C6H5N3O

  • Molecular Weight: 135.12 g/mol

  • Synonyms: HOBt

  • Packaging: 25 kg fiber drum

  • Solubility: Soluble in polar organic solvents

  • Storage: Store in a dry, inert atmosphere

  • Toxicity: Explosive when dry; handle under controlled conditions

Applications:

  • Amide bond formation in peptide synthesis

  • Synthesis of esters and activated carboxylic derivatives

  • Pharmaceutical R&D

Description provided by Avd Pharmaceuticals Private Limited.

1-Hydroxybenzotriazole Anhydrous (HOBt Anhydrous)

Peptide bond formation and acylation catalyst

Prevents racemization and improves yields in carbodiimide-mediated coupling

Anhydrous, moisture-sensitive powder

25 kg fiber drum

Soluble in polar organic solvents

Store in dry, inert atmosphere; handle carefully due to explosive nature when dry

Pharmaceutical peptide synthesis, ester synthesis, activated carboxylic derivatives

2592-95-2

135.12 g/mol

Specifications
Molecular Formula
C6H5N3O
CAS Number
2592-95-2
Physical State
Solid, crystalline powder
Purity
High purity, anhydrous grade
Storage Conditions
Store under inert gas in dry environment
Hazard Information
Explosive when dry; requires controlled handling
Recommended Usage
Use under strictly anhydrous conditions for optimal performance
Solubility
Soluble in polar organic solvents such as DMF, DMSO
Packaging Details
Available in 25 kg fiber drums to maintain integrity and safety
Use cases
Category
healthcare > apis > api intermediate
Primary application
Brand
Not specified
Product type
Product
Logistics & handling
Lead time
On request
Packaging
As per buyer requirement
Storage condition
As recommended by supplier
Origin
India
Form
As listed by supplier
Commercials Avd Pharmaceuticals Private Limited
Minimum order
1 unit
Lead time
On request
Payment terms
As per negotiated commercial agreement
Frequently asked by buyers
How does the anhydrous form of 1-Hydroxybenzotriazole differ from its hydrated counterpart in peptide synthesis?

The anhydrous form of 1-Hydroxybenzotriazole is significantly more reactive and moisture-sensitive, making it suitable for strictly anhydrous peptide synthesis conditions where high-purity and improved coupling efficiency are required. Its use minimizes side reactions and racemization compared to hydrated forms.

What safety precautions must be taken when handling 1-Hydroxybenzotriazole Anhydrous?

Because 1-Hydroxybenzotriazole Anhydrous is explosive when dry, it must be handled under controlled conditions with proper personal protective equipment, in a dry and inert atmosphere, avoiding friction, heat, or contamination with incompatible materials.

Which solvents is 1-Hydroxybenzotriazole Anhydrous compatible with for optimal solubility?

It is highly soluble in polar organic solvents such as dimethylformamide (DMF) and dimethyl sulfoxide (DMSO), which are commonly used in peptide coupling reactions for better reagent performance.

What packaging format is available for industrial and laboratory use of HOBt anhydrous?

HOBt Anhydrous is typically supplied in 25 kg fiber drums designed to maintain the chemical's anhydrous condition and ensure safe transportation and storage for industrial and professional lab environments.

In which types of pharmaceutical synthesis is 1-Hydroxybenzotriazole Anhydrous most valuable?

It is most valuable in pharmaceutical peptide synthesis, ester synthesis, and the generation of activated carboxylic derivatives where racemization prevention and high coupling yields are crucial.

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1- Hydroxy benzotriazole anhydrous (HOBT)
1- Hydroxy benzotriazole anhydrous (HOBT)
₹ 19.59 /unit