SITAJAN MET 50/500 Tablet is a dual-action oral hypoglycemic agent that combines Sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, with Metformin Hydrochloride, a biguanide antihyperglycemic agent. This fixed-dose combination has been developed to treat type 2 diabetes mellitus in adult patients who require enhanced glycemic control beyond Metformin monotherapy.
The 50 mg of Sitagliptin in SITAJAN MET enhances the body's natural ability to lower blood glucose by increasing levels of active incretin hormones. These hormones help stimulate insulin release and reduce glucagon secretion in response to meals, leading to better regulation of postprandial blood sugar. Sitagliptin is known for its glucose-dependent mechanism of action, which significantly reduces the risk of hypoglycemia and is weight-neutral.
Metformin Hydrochloride 500 mg, the second component, works primarily by reducing hepatic glucose production and increasing peripheral glucose uptake and utilization. It improves insulin sensitivity without increasing insulin secretion, thus addressing the insulin resistance component of type 2 diabetes. Metformin is also associated with modest weight loss or weight neutrality, which benefits overweight or obese diabetic patients.
SITAJAN MET 50/500 provides a synergistic therapeutic approach by combining these mechanisms. It is typically administered twice daily with meals to minimize gastrointestinal side effects and ensure optimal bioavailability. The dose is often titrated based on patient response and tolerability under a physician’s supervision.
This formulation is manufactured by Bluepill Express, adhering to WHO-GMP, ISO 9001, and Schedule M standards in fully compliant facilities equipped with automated manufacturing lines. The production process includes precision blending, granulation, tablet compression, and film coating, ensuring uniform drug content and prolonged stability.
Strict quality control protocols are followed at every stage—raw material testing, in-process checks, and final product analysis—to meet international regulatory requirements. The tablets are packed in blister or alu-alu packaging to ensure protection from moisture and contamination, with options available for custom branding, export labeling, and private labeling.
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