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3D-MPLA-4A

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Swasti Exports
Manufacturer, Trader, Exporter, Importer — Vadodara, Gujarat, India · Replies in ~24–48 hours
Trusted Seller FIEO Registered Export Ready
Price on request In stock
MOQ: 1 unit
Lead time: On request
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Origin: India
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Export Snapshot
Minimum order
1 unit
HSN Code
On request
Origin
India
Lead time
On request
Port of dispatch
On request
Packaging
Standard export packaging
Shelf life / storage
As per product specification
Export markets served
Chile flag CL United Arab Emirates flag AE United Kingdom flag GB United States flag US United States Minor Outlying Islands flag UM
Ability to customise
As per OEM brief
Values shown are for Swasti Exports.
IEC Certificate
Company Swasti Exports
Swasti Exports logo
Swasti Exports

We are Merchant Exporter and supplying Chemicals, Agriculture products, Rices, spices, Kashmiri Saffron, Iranian saffron, Dates and so many products.

Registered address: Vadodara, India. Industry: Chemicals, Dyes & Paints › Chemical Industry Related Services.

Trusted Seller FIEO Registered
View profile →
Established
2020
Employees
1–10
GST
24AIXPB0733C1ZO
IEC code
AIXPB0733C
Export markets
Chile flag CL United Arab Emirates flag AE United Kingdom flag GB United States flag US United States Minor Outlying Islands flag UM
Member since
Jul 2020
Turnover
Less than $50,000
Incorporation type
On request
Product details
Specifically engineered for immunological research, this variant is a key molecular probe for deciphering the Structure-Activity Relationship (SAR) of TLR4 receptors.Compared to the potent hexa-acyl (6A) version, the 4A variant exhibits minimal activity in human immune cells and functions as a potential TLR4 antagonist. It holds significant promise as a therapeutic lead for autoimmune and allergic diseases.Quality level: Research grade
Description provided by Swasti Exports.

3-O-deacylated-4'-monophosphoryl lipid A (3-DMPLA)

4-acylated (tetra-acyl) variant

Derived from Lipopolysaccharide (LPS) of Salmonella minnesota Re595

Designed for immunological research and TLR4 structure-activity relationship studies

Minimal activity in human immune cells compared with hexa-acyl MPLA

Investigated as a potential TLR4 antagonist and therapeutic lead

Specifications
Product Title
3D-MPLA-4A
Full Chemical Name
3-O-deacylated-4'-monophosphoryl lipid A (3-DMPLA)
Acylation State
4-acylated
Lipid Chain Structure
Tetra-acyl carbon chain structure
Source Organism
Salmonella minnesota Re595
Material Type
Lipopolysaccharide-derived lipid A derivative
Quality Level
Research grade
Target Receptor
TLR4
Research Area
Immunology, inflammatory signaling, receptor biology
Functional Profile
Low immunostimulatory activity
Use cases
Category
Research Chemicals > Immunology Reagents > TLR4 Ligands
Primary application
Wholesale, distribution and international sourcing
Product type
Product
Logistics & handling
Lead time
On request
Packaging
As per buyer requirement
Storage condition
As recommended by supplier
Origin
India
Form
As listed by supplier
Commercials Swasti Exports
Minimum order
1 unit
Lead time
On request
Payment terms
As per negotiated commercial agreement
Frequently asked by buyers
How does the 4-acylated 3D-MPLA-4A differ from hexa-acyl MPLA in TLR4 research?

The 4-acylated 3D-MPLA-4A has a tetra-acyl chain structure and shows minimal activity in human immune cells, while hexa-acyl MPLA is more potent. This makes the 4A variant more suitable for studying reduced TLR4 activation and receptor structure-activity relationships.

Why is Salmonella minnesota Re595 used as the source for this lipid A derivative?

Salmonella minnesota Re595 is a well-characterized source of LPS-derived lipid A molecules, making it useful for producing defined analogs like 3D-MPLA-4A for reproducible immunological studies.

What type of studies is 3D-MPLA-4A best suited for?

It is best suited for TLR4 signaling studies, receptor-binding analysis, structure-activity relationship (SAR) investigations, and research into immune modulation relevant to autoimmune and allergic disease pathways.

Can 3D-MPLA-4A be used to evaluate TLR4 antagonism?

Yes. Because it exhibits minimal activity in human immune cells, it is often explored as a potential TLR4 antagonist or immune-response modulator in experimental settings.

What makes this product valuable as a therapeutic lead?

Its reduced immunostimulatory activity and defined interaction profile with TLR4 make it a useful lead compound for researchers exploring therapies for autoimmune and allergic disorders.

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3D-MPLA-4A
3D-MPLA-4A
Price on request